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In this review, we discuss the development of loc and its research progress in liver diseases, hepatotoxicity tests, and drug screening, as well as chip combinations. By identifying conserved cell cycle genes predictive of regenerative outcomes, this study offers a powerful framework to assess and potentially enhance liver recovery in older patients, those with fibrosis or steatosis, and/or those under immunosuppression. Liver organoids possess the same structure and function as liver tissue, offering the potential to serve as a viable replacement for the liver, aligning with the goals of regenerative medicine
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This review examines the role of liver organoids in regenerative medicine. Taken together, our work dissects unanticipated aspects of liver regeneration, demonstrating an uncoupling of wound closure and hepatocyte proliferation and uncovering a novel migratory hepatocyte subpopulation which mediates wound closure following liver injury. In this study, we utilized transcriptomic and proteomic profiling to identify genes, proteins, signaling pathways, and biological processes involved in liver regeneration following 75% hepatectomy under various clinical contexts, including sex, age, fibrosis, steatosis, and immunosuppression.
These systems can be used to discover new drugs, study their biotransformation, and test their toxicities.
